2.
MMR蛋白表达与结直肠癌临床病理特征的关系
Correlation between clinicopathological characteristics and MMR protein expression in colorectal cancer [n(%)]
| Parameters | n (%) | MMR proteins expression | P | |
| dMMR | pMMR | |||
| Gender | ||||
| Male | 862(61.8) | 69(65.1) | 793(61.6) | 0.473 |
| Female | 532(38.2) | 37(34.9) | 495(38.4) | |
| Age (year) | ||||
| < 50 | 282(20.2) | 42(39.6) | 240(18.6) | < 0.001 |
| ≥50 | 1112 (79.8) | 64(60.4) | 1048 (81.4) | |
| Location | ||||
| Right colon | 367(26.3) | 68(64.1) | 299(23.2) | < 0.001 |
| Left colon | 489(35.1) | 29(27.4) | 460(35.7) | |
| Rectum | 538(38.6) | 9(8.5) | 529(41.1) | |
| Gross type | ||||
| Ulcerative | 779(55.9) | 52 (49.1) | 727(56.4) | 0.032 |
| Protuberant | 575(41.2) | 54 (50.9) | 521(40.5) | |
| Infiltrating | 40(2.9) | 0 (0) | 40(3.1) | |
| Tumor size (cm) | ||||
| < 3 cm | 285(20.4) | 7(6.6) | 278(21.6) | < 0.001 |
| 3-6 cm | 872(62.6) | 47(44.3) | 825(64.1) | |
| > 6 cm | 237(17.0) | 52(49.1) | 185(14.3) | |
| Histological classification | ||||
| Adenocarcinoma | 1147 (82.2) | 63(59.4) | 1084 (84.2) | < 0.001 |
| Adenocarcinoma with mucous adenocarcinoma | 139(10.0) | 28(26.4) | 111 (8.6) | |
| Mucous adenocarcinoma | 93(6.7) | 14(13.2) | 79(6.1) | |
| Signet ring cell Carcinoma | 15(1.1) | 1(1.0) | 14(1.1) | |
| Differentiation | ||||
| Well | 121 (8.7) | 12(11.3) | 109 (8.4) | < 0.001 |
| Moderate | 1065 (76.4) | 53(50.0) | 1012 (78.5) | |
| Poor | 117 (8.4) | 27(25.5) | 90(7.0) | |
| Mucinous adenocarcinoma | 91(6.5) | 14(13.2) | 79(6.1) | |
| Lymph node metastasis | ||||
| With | 599(43.0) | 29(27.4) | 570(44.3) | 0.001 |
| Without | 795(57.0) | 77(72.6) | 718(55.7) | |
| TNM stage | ||||
| I and II | 785(56.3) | 76(71.7) | 709(55.0) | 0.001 |
| III and IV | 609(43.7) | 30(28.3) | 579(45.0) | |