1.
158例RUNX1基因突变及野生型AML患者的临床特征
Characteristics of 158 AML patients with and without RUNX1 mutations
| Clinical characteristic | Total (n=158) | RUNX1mutated (n=19; 12.0%) | RUNX1wildtype (n=139; 88.0%) | P |
| Male/Female | 158 | 11/8 | 78/61 | 0.883 |
| Median age(year, range) | 55.0 (45.0-65.0) | 66.0 (51.0-75.0) | 53.0 (43.0-63.5) | 0.009 |
| Median WBC count, ×109/L (range) | 15.2 (2.7-68.4) | 15.7 (3.2-89.7) | 14.7 (2.1-67.7) | 0.583 |
| Median Hb, g/L (range) | 76.0 (59.3-89.8) | 72.0 (59.0-86.0) | 76.0 (59.5-90.0) | 0.726 |
| Median Plt, ×109 (range) | 34.5 (19.0-67.0) | 40.0 (19.0-95.0) | 34.0 (18.5-63.5) | 0.247 |
| Median BM blasts (range) | 78.1 (50.5-90.1) | 63.6 (39.5-84.1) | 78.7 (55.7-90.2) | 0.321 |
| LDH | 399.0 (230.0-785.0) | 414.5 (264.8-1046.0) | 399.0 (222-770) | 0.452 |
| FAB subtype (157 analysis) | ||||
| M1 | 13 | 2 | 11 | 1.000 |
| M2 | 62 | 4 | 58 | 0.079 |
| M3 | 15 | 0 | 15 | 0.274 |
| M4 | 29 | 6 | 23 | 0.209 |
| M5 | 37 | 7 | 30 | 0.244 |
| M6 | 1 | 0 | 1 | 1.000* |
| Surface antigen positivity | ||||
| CD34+ | 72 | 10/9 | 62/77 | 0.510 |
| HLA-DR+ | 76 | 12/7 | 64/75 | 0.161 |
| CD117+ | 110 | 11/8 | 99/40 | 0.236 |
| CD13+ | 64 | 9/10 | 55/84 | 0.516 |
| CD33+ | 65 | 6/13 | 59/80 | 0.367 |
| CD38+ | 68 | 10/9 | 58/81 | 0.368 |
| CD64+ | 34 | 5/14 | 29/110 | 0.807 |
| CD36+ | 20 | 5/14 | 15/124 | 0.123 |
| CD7+ | 14 | 4/15 | 10/129 | 0.118 |