Fig. 6.

Signature based re-classification of patients in the test (CT, MODS and ECMO) dataset and validation dataset. (a) Heatmaps showed the clustering of signature genes in ECMO patients compared to control (CT) and MODS patients. Risk scores derived from the signature genes showed difference in (b) ECMO and MODS in our data, and in (c) MODS (require ICU support similar to our ECMO patients) and noMODS (do not require ICU support similar to our MODS patients) in the validation data (Cabrera et at., 2017) [10]. (d) Receiver operating characteristics (ROC) of the classification using our data and the validation data. A risk score for each patient was computed based on the geometric mean of the signature gene expression. Risk scores were strongly associated with ECMO and can be helpful to predict the probability of the MODS patients who require ECMO support.