Table 4.
Higher inflammatory levels in IPERGAY men compared to COHVAC men
| Univariate a |
Multivariate b |
|||
|---|---|---|---|---|
| Estimate (95%CI) | P-value | Estimate (95%CI) | P-value | |
| TNF-α, pg/mL | ||||
| COHVAC | Ref. | – | Ref. | – |
| IPERGAY | 0·83 (0·42, 1·24) | < 0·0001 | 0·73 (0·22, 1·23) | 0·01 |
| Age, years | 0·01 (−0·02, 0·03) | 0·56 | 0·02 (−0·01, 0·04) | 0·14 |
| Alcohol consumer | 0·61 (0·19, 1·03) | 0·01 | 0·25 (−0·23, 0·73) | 0·30 |
| Current smoker | 0·38 (−0·10, 0·86) | 0·12 | 0·07 (−0·44, 0·57) | 0·79 |
| sTNFRII, pg/mL | ||||
| COHVAC | Ref. | – | Ref. | – |
| IPERGAY | −345 (−630, −59) | 0·02 | −286 (−640, 68) | 0·11 |
| Age, years | 13 (−3, 29) | 0·12 | 10 (−7, 26) | 0·26 |
| Alcohol consumer | −225 (−515, 64) | 0·13 | −67 (−406, 272) | 0·70 |
| Current smoker | −116 (−445, 213) | 0·49 | 44 (−308, 396) | 0·80 |
| IL-17, pg/mL | ||||
| COHVAC | Ref. | – | Ref. | – |
| IPERGAY | 0·48 (0·21, 0·76) | 0·001 | 0·48 (0·18, 0·80) | 0·001 |
| Age, years | −0·01 (−0·02, 0·01) | 0·43 | −0·00 (−0·02, 0·02) | 0·87 |
| Alcohol consumer | 0·30 (0·02, 0·58) | 0·04 | 0·09 (−0·23, 0·42) | 0·57 |
| Current smoker | 0·04 (−0·28, 0·37) | 0·80 | −0·19 (−0·53, 0·15) | 0·28 |
| I-FABP, pg/mL | ||||
| COHVAC | Ref. | – | Ref. | – |
| IPERGAY | 251 (69, 432) | 0·01 | 154 (−67, 375) | 0·17 |
| Age, years | 1 (−9, 12) | 0·80 | 5 (−5, 16) | 0·34 |
| Alcohol consumer | 230 (48, 413) | 0·01 | 126 (−86, 339) | 0·24 |
| Current smoker | 221 (12, 430) | 0·04 | 136 (−86, 359) | 0·23 |
a
Results from linear regression models.
b
Results from a multiple linear regression adjusted for age, alcohol, and smoking
Abbreviations: 95%CI, 95% confidence interval; Ref. Reference
See Supplementary Table 3 for us-CRP, IL-6, sTNFRII, CXCL10, sCD14, sCD163 and hyaluronic acid.