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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Heart Rhythm. 2020 Jun 6;17(12):2180–2189. doi: 10.1016/j.hrthm.2020.05.041

Figure 5: Validation of trafficking scores.

Figure 5:

Validation of selected variants by analytical flow cytometry (left) and confocal microscopy (right). In the leftmost column, DMS score is indicated directly below variant name. X-axis is mCherry fluorescence (indicating KV11.1 expression), the y-axis is surface stained KV11.1. The remaining columns are extracellularly stained KV11.1 (AF647, purple) intracellularly stained KV11.1 (AF488, green), and both merged with DAPI stained nucleus (blue).