Table 2.

Counts of circulating PD-1⁺ and TIM-3⁺ T cell subsets in multiple myeloma patients.

Cell subset	Healthy donors (n = 28)	Patients in CR/PR (n = 50)	Patients with progressive disease (n = 10)
CD4+PD-1+, %	4.4 (2.6–5.3)	6.1 (4.7–9.8)*	11.8 (7.3–13.4)*#
CD4+TIM-3+, %	0.6 (0.4–1.0)	1.3 (0.8–2.3)*	2.0 (1.2–2.5)*
CD8+PD-1+, %	1.6 (1.1–3.2)	2.9 (1.6–4.1)*	3.9 (1.3–12.2)*
CD8+TIM-3+, %	3.1 (1.8–5.4)	3.8 (2.4–5.7)*	8.9 (4.8–12.0)*#

Relative counts are presented as the percentages of lymphocytes.

Data are presented as median (interquartile range). P values are assessed with Mann–Whitney U-test.

CR complete remission; PR partial response.

*P_U < 0.05 between healthy donors and patients.

^#P_U < 0.05 between patients in CR/PR and patients with progressive disease.