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. 2020 Nov 30;11:6119. doi: 10.1038/s41467-020-19973-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Quantitative real-time PCR (qRT-PCR) analysis of CCL7 mRNA in primary tumor and adjacent normal tissues of NSCLC patients (n = 18). b qRT-PCR analysis of CCL7 mRNA in primary tumor and adjacent normal tissues of NSCLC patients (n = 44). c Immunohistochemistry (IHC) staining (left images) and integrated optical density (IOD) analysis (right graphs) of CCL7 in tissue array of tumor and adjacent normal tissues from NSCLC patients (n = 287). d Overall survival (OS) of NSCLC patients (n = 287) based on the CCL7 protein levels. e A scheme of KP and KP7^ZsGreen mice intranasally injected with Ad-Cre for 10 weeks followed by flow cytometry analysis (upper scheme). Flow cytometry analysis of single-cell suspensions of lungs from KP and KP7^ZsGreen mice as treated in the above scheme (lower flow charts). f Flow cytometry analysis of immune cells in the bronchial draining lymph nodes from KP and KP7^ZsGreen mice treated as in e. g Flow cytometry analysis of immune cells in the lung infiltrated lymphocytes from KP and KP7^ZsGreen mice treated as in e. Two-tailed student’s t-test (a–c) and Log-rank analysis (d). T, tumor tissue; N, normal tissue; Stroma, stromal cell; Endo, endothelial cell; Tumor, tumor cell; cDC1, conventional dendritic cell 1; AM, alveolar macrophage. Graphs show mean ± SEM (a–c). Scale bars, 100 μm (c). Data are representative of two independent experiments (e–g). Source data are provided as a source data file.