Fig. 4. Genome-wide scan for recent positive selection in the UK Biobank dataset.

Manhattan plot with candidate gene labels for 12 loci detected at genome-wide significance (adjusting for multiple testing, approximate 1-sided DRC₅₀ p < 0.05/52,003 = 9.6 × 10⁻⁷; dashed red line). The DRC₅₀ statistic of shared recent ancestry within the past 50 generations was computed using 487,409 samples within the UK Biobank cohort. FastSMC detected 5 loci known to be under recent positive natural selection (gene labels in black) and 7 novel loci (in red). The corresponding p-values are reported in Supplementary Table 4.