Figure 2.

SPINK1 patients with a history of abdominal pain ranging from 4 to < 7 years. The pancreata exhibited a progressive loss of acinar parenchyma with coinciding mild interlobular and mild perilobular fibrosis. Fibrosis was typically composed of thick bundles of collagen, fibroblasts and scattered islands of neutrophilic inflammation (A and B). A brisk acute inflammatory infiltrate was also seen present within the pancreatic lobules (C and D).