Figure 4.

SPINK1 carriers with a history of abdominal pain that ranged between 21 and 25 years. Pancreatic specimens exhibited near complete to complete loss of acinar and ductal epithelium, and extensive parenchymal fibrosis (A and B). The remnant exocrine pancreas consisted primarily of a dilated main pancreatic duct and associated interlobular ducts (C). Scattered foci of reactive and hyperplastic intralobular ducts were also identified (D). At higher magnification, residual islets of Langerhans were found scattered throughout the pancreas but embedded in dense fibrosis (E and F).