. Author manuscript; available in PMC: 2021 May 28.

Published in final edited form as: Adv Drug Deliv Rev. 2020 May 28;154-155:245–273. doi: 10.1016/j.addr.2020.05.006

Table 4.

Mechanism of the CHMs that resolve phlegm and eliminate dampness and their active components on tumor cells and the TME.

CHMs	Active components	Tumor cells					TME	References
CHMs	Active components	Apoptosis induction	Proliferation inhibition	Autophagy regulation	Anti-multidrug resistance	Migration and invasion inhibition	Anti-angiogenesis	References
Acorus tatarinowii schott (shi chang pu)	Alpha-asarone	√	√	√	√	√		[263,264]
Rhizoma alismatis (ze xie)	Alisol B and Alisol B23-acetate	√	√	√	√	√		[265,266]
Angelica dahurica (bai zhi)	Imperatorin and Isoimperatorin		√		√	√	√	[267–270]
Fructus citri sarcodactylis (fo shou)	Bergapten	√	√			√		[271,272]
	Diosmetin	√	√			√	√	[273,274]
	Diosmin	√	√					[275]
	Hesperidin and Hesperetin	√	√		√	√	√	[276–278]
Dried tangerine peel (chen pi)	Nobiletin	√	√		√	√	√	[279–281]
Dried tangerine peel (chen pi)	Tangeretin	√	√		√	√		[282–284]
Magnolia bark (hou pu)	Magnolol and Honokiol	√	√	√	√	√	√	[285,286]
Pipernigrum (hu jiao)	Piperine, Citronellal, and Piperlongumine	√	√	√	√	√	√	[287–290]