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. Author manuscript; available in PMC: 2021 Nov 25.
Published in final edited form as: Neuron. 2020 Oct 21;108(4):735–747.e6. doi: 10.1016/j.neuron.2020.09.022

Figure 4. Sharply tuned monocular neurons gain matched responses from the other eye and become binocular.

Figure 4.

(A) Tuning measures for monocular contralateral neurons which became binocular (M2B, 138 neurons) or remained monocular (M2M, 516 neurons) between P22-29 and P29-36. Each dot represents a cell with circular variance, spatial frequency and F1/F0 (color bar), prior to the transition.

(B) Tuning density profiles of monocular contralateral neurons. Cells that became binocular (M2B, green) have higher spatial frequency and lower circular variance than those that remained monocular (M2M, red).

(C) Receptive field tuning measurements in panel A, and matching coefficients for newly formed (M2B, n=138) and lost (B2M, n= 182) binocular neurons. Black dot, median; gray vertical lines, quartiles with whiskers extending to 2.698σ. P-values, Mann-Whitney U-test.

(D) Neurons experience large and discrete jumps in SNR as they gain responsiveness to an eye. Boxplots of SNR changes of tuning kernels. Stable: changes in SNR for stably responsive, contralateral eye tuning kernels. Gained: SNR changes for the newly-responsive ipsilateral eye tuning kernels. Change is plotted as fold of std of noise SNR. Gained, n = 136; Stable, n = 516. P-values, Mann-Whitney U-test. P-values are corrected for multiple comparisons as the Stable pool was used in Figure 3 as well.

(E) Schematic showing that the fates of monocular neurons are determined by their tuning properties. M2M, monocular neurons that remain monocular; M2B, monocular neurons that become binocular. The width of the gaussian above the arrows reflects orientation tuning selectivity – narrower is more selective. Spatial frequency is depicted by the circle above the arrows – more lines indicates higher spatial frequency preferences. Monocular neurons with broad orientation tuning and lower spatial frequency preferences remain monocular (top). Those with greater orientation tuning selectivity and higher spatial frequency preferences gain matched input from the other eye and become binocular (bottom)