(A) Subjects were randomized to the eight-week exercise training intervention (ET) or non-exercise control (CON). VO2 peak testing and acute exercise trial were completed pre- and post-intervention. (B) Acute Exercise Trial: After a baseline blood draw, subjects cycled on a stationary cycle ergometer for 30 minutes at 70% VO2 peak. Following the acute exercise trial (Time 0), blood was drawn at 10-min, 30-min, 1-hr, 4-hrs, 8-hrs and 24-hrs post-exercise. For time-course comparisons all time points were normalized to the individuals’ baseline blood draw. Acute exercise trial time course responses were tested before and after the intervention.