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. Author manuscript; available in PMC: 2021 Nov 20.
Published in final edited form as: Free Radic Biol Med. 2020 Aug 28;160:418–432. doi: 10.1016/j.freeradbiomed.2020.08.016

Figure 3. Nrf2 signaling responses to a single acute exercise session by age and sex.

Figure 3.

All responses are normalized to the individual’s baseline draw (B) and set equal to 1 in order to control for any differences in absolute expression levels across individuals. (A) Representative Nrf2 western blots with Lamin B used as internal control, for an older man, older woman, young man, and young woman pre-Intervention. (B) Nrf2 signaling responses in young and older men. Black squares indicate response in young men and open circles indicate response in older men across time. (C) Young women (black squares) and older women (open circles) showed minimal Nrf2 signaling responsiveness to an acute exercise bout and were not significantly different from each other. Analyzed together with fitness and body composition covariates in the model, there was a significant main effect of age with young individuals showing a higher response in Nrf2 activation than older individuals (RM ANCOVA Age p = 0.05). Data shown as Mean ± SEM.