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. Author manuscript; available in PMC: 2021 Nov 20.
Published in final edited form as: Free Radic Biol Med. 2020 Aug 28;160:418–432. doi: 10.1016/j.freeradbiomed.2020.08.016

Figure 4. Nrf2 signaling responses to acute exercise before and after exercise training or inactive control intervention by age.

Figure 4.

Open circles indicate Nrf2 activation pre-intervention, and black squares indicate Nrf2 activation post-intervention. Panels A, C, & E are ET subjects while panels B, D, & F are CON subjects. (A&B) Eight weeks of aerobic exercise training increased the Nrf2 signaling response to an acute exercise bout in the whole cohort, while the Nrf2 signaling in the control group did not change. (C&E) The increase in Nrf2 signaling after training was similar in pattern for young and older adults, although young improved their responses to a greater degree than older ET subjects (main effect of age, p = 0.014). (D&F) Nrf2 signaling did not change from pre-intervention in older or young control groups. Representative western blots for (G) Young-ET, (H) Young-CON, (I) Older-ET, and (J) Older-CON. Data shown as Mean ± SEM.