Open circles indicate NQO1 mRNA responses to the acute exercise trial pre-intervention, while black squares indicate responses post-intervention. (A&B) In the whole cohort, there was a slight increase in NQO1 mRNA response after training, which was dependent on baseline Nrf2 expression changes (Δ Baseline Nrf2), but no difference in response after control intervention. (C&E) This increase in NQO1 mRNA response after ET appears to be driven by younger individuals, not older. (D&F) Post-control intervention older individuals show a decreased response while younger controls show a delayed increase in NQO1 mRNA driven by one outlier in the post-intervention CON response. Panels A, C, & E are ET subjects, while B, D, & F are CON subjects. Data shown as Mean ± SEM.