Open circles are pre-intervention GCLC mRNA responses and black squares are post-intervention responses. Panels A, C, & E are ET subjects and B, D, & F are CON subjects. (A&B) Overall comparison of intervention, time, and training group responses to the acute exercise trial. There were significant interactions between intervention, time, and training group in GCLC mRNA response (p = 0.05) as well as an intervention by time by ΔBaseline GCLC protein interaction (p = 0.001). (C-F) Show acute exercise trial responses by age and training group. Data shown as Mean ± SEM.