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. Author manuscript; available in PMC: 2021 Nov 20.
Published in final edited form as: Free Radic Biol Med. 2020 Aug 28;160:418–432. doi: 10.1016/j.freeradbiomed.2020.08.016

Figure 9. Baseline expression of Nrf2 and GCLC before and after ET or CON.

Figure 9.

(A) Representative blot images for young and older ET and CON individuals for Nrf2 and GCLC protein expression respectively. (B) Baseline Nrf2 protein expression was higher in older adults before the exercise intervention compared to young (independent sample t test, p = 0.004) but decreased with ET closer to young Nrf2 expression levels. Older controls showed the opposite pattern, increasing baseline Nrf2 expression after eight weeks of CON. Repeated measures ANCOVA shows a significant interaction between training group and pre-post intervention (p = 0.032). The majority of these differences are explained by age differences (p < 0.001) (C) There was no change in GCLC protein in young trained or control subjects. In older subjects there was no significant difference in basal GCLC protein after training or control interventions. Data shown as Mean ± SEM.