Table 6.
The probability of toxic exposures as predicted by MCS for each simulated regimen at various EMCO rates
| Dosing regimen | ECMO rate (mL/min) | Probability of toxicity (%) (AUCtotal ≥ 550) (mean AUC mg*h/L, SD) | Probability of toxicity (%) (AUC total ≥ 515) (mean AUC mg*h/L, SD) |
|---|---|---|---|
| 1000 mg BID | |||
| 3500 | 12 (452.05, SD: 114.21) | 19.8 (452.05, SD: 114.21) | |
| 3820 | 11.9 (451.83, SD: 114.14) | 19.6 (451.83, SD: 114.14) | |
| 4000 | 11.9 (451.73, SD: 114.11) | 19.5 (451.73, SD: 114.11) | |
| 4500 | 11.8 (451.02, SD: 114.02) | 19.4 (451.47, SD: 114.02) | |
| 5000 | 11.8 (451.26, SD: 113.95) | 19.2 (451.26, SD: 113.95) | |
| 1500 mg BID | |||
| 3500 | 82.4 (678.08, SD: 171.33) | 92.1 (678.08, SD: 171.33) | |
| 3820 | 82.3 (677.75, SD: 171.21) | 92.1 (677.75, SD: 171.21) | |
| 4000 | 82.2 (677.59, SD: 171.16) | 92.1 (677.59, SD: 171.16) | |
| 4500 | 82.1 (677.2, SD: 171.03) | 92.1 (677.2, SD: 171.03) | |
| 5000 | 82 (676.88, SD: 170.92) | 92.1 (676.88, SD: 170.92) | |
| 2000 mg BID | |||
| 3500 | 99.9 (904.1, SD: 228.43) | 100 (904.1, SD: 228.43) | |
| 3820 | 99.9 (903.66, SD: 228.28) | 100 (903.66, SD: 228.28) | |
| 4000 | 99.9 (903.44, SD: 228.21) | 100 (903.44, SD: 228.21) | |
| 4500 | 99.9 (902.93, SD: 228.03) | 100 (902.93, SD: 228.03) | |
| 5000 | 99.9 (902.51, SD: 227.89) | 100 (902.51, SD: 227.89) | |
ECMO extracorporeal membrane oxygenation, BID twice a day, MCS Monte Carlo simulation, AUC area under the curve, SD standard deviation