Table 7.
Population parameter value covariance matrix
| V0 | V2 | V3 | CL0 | Q1 | Q2 | K34 | |
|---|---|---|---|---|---|---|---|
| V0 | 131.437 | – | – | – | – | – | – |
| V2 | − 11.495 | 38.522 | – | – | – | – | – |
| V3 | − 2.191 | 0.722 | 0.15 | – | – | – | – |
| CL0 | 5.427 | −1.67 | −0.071 | 5.436 | – | – | – |
| Q1 | 22.95 | −19.79 | −0.33 | 3.895 | 15.142 | – | – |
| Q2 | − 42.634 | − 11.593 | 1.209 | 1.142 | 2.798 | 26.788 | – |
| Kout | − 3.424 | 0.06 | 0.028 | −0.3 | − 0.869 | 0.933 | 0.296 |
V0 volume term, V2 volume peripheral compartment, V3 volume in the ECMO compartment, CL0 clearance term, Q1 intercompartment flow rate 1, Q2 intercompartment flow rate 2, K31 rate constant to central compartment from ECMO compartment, Kout ECMO drug sequestration/elimination