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. 2020 Dec 1;9:20. doi: 10.1186/s13619-020-00058-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Mesenchymal stem cells (MSCs) Mechanism of Action for Scleroderma Treatment. MSCs can play a role in scleroderma treatment via different mechanism such as an anti-fibrotic effect on collagen accumulation, proangiogenic effect against vasculopathy, and anti-inflammatory and immunomodulatory effects (Peltzer et al. 2018; Lim et al. 2017; Akiyama et al. 2012; Chen et al. 2017a; Maria et al. 2016b)