Table 2.
Final Cox Regression Model for 5-Year Recurrent ASCVD Event Risk Prediction
| Parameter | Beta | Wald Chi-sq | P value | HR (95% CI)* |
|---|---|---|---|---|
| Age, per 1 SD | 0.00212 | 0.1735 | 0.677 | 1.02 (0.93-1.11) |
| Sex, 1=male,0=female | 0.32063 | 5.9028 | 0.015 | 1.38 (1.06-1.79) |
| Race, l=White, 0=Non-White | 0.02306 | 0.0226 | 0.881 | 1.02 (0.76-1.38) |
| Alcohol use, l=Yes, 0=No | 0.19119 | 5.4328 | 0.020 | 0.83 (0.70-0.97) |
| Family history of CVD, 1=Yes, 0=No | 0.25629 | 9.7769 | 0.002 | 1.29 (1.10-1.52) |
| HbA1c per 1SD | 0.11435 | 5.3807 | 0.020 | 1.10 (1.01-1.19) |
| BMI, per 1 SD | 0.01358 | 3.1488 | 0.076 | 1.08 (0.99-1.16) |
| Serum creatinine, per 1 SD | 0.3446 | 3.8394 | 0.050 | 1.09 (1.00-1.18) |
| Homocysteine, per 1 SD | 0.01336 | 8.8025 | 0.003 | 1.08 (1.03-1.13) |
| Lp(a), per 1 SD | 0.00174 | 18.7007 | <.0001 | 1.07 (1.04-1.10) |
| History of heart failure | 0.27109 | 3.8023 | 0.051 | 1.31 (1.00-1.72) |
| History of carotid artery disease | 0.31782 | 9.1159 | 0.003 | 1.37 (1.12-1.69) |
Final Risk Score:
Potential risk factor list: age, sex, race, smoking status, alcohol consumption, family history of CVD, diabetes, atrial fibrillation history, body mass index, systolic and diastolic blood pressure, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, triglycerides, lipoprotein(a), Apolipoprotein AI, Apolipoprotein B, serum creatine, homocysteine, and treatment assignment.
HRs are presented per 1 SD increase of continuous variables; beta coefficients are presented in original units. BMI=body mass index; lp(a)=lipoprotein(a) 1 SD of age= 8.75 years; 1SD of BMI =5.33 kg/m2; 1SD of serum creatinine=0.24 mg/dL; 1 SD of Lp(a)=37.02 nmol/L; 1SD of Homocysteine=11.36 umol/L.