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Bar graphs (mean ± SEM) depicting changes in left ventricular (LV) end-diastolic volume (EDV) (top left), end-systolic volume (top right), ejection fraction (bottom left) and cardiac output (bottom right) in untreated control cardiorenal syndrome (CRS-CON) dogs (n=7) and in CRS dogs treated with sacubitril/valsartan (CRS+Sac/Val) (n=7). Data time points are before initiating therapy (PRE) and 2 weeks, 1 month and 3 months after initiating therapy. *=p<0.05 vs. PRE.
