TABLE 4.
Histomorphometric findings in LV myocardium of normal dogs (NL), untreated cardiorenal syndrome (CRS) control dogs (CRS-CON) and CRS dogs treated with Sac/Val (CRS+Sac/Val).
| Normal (n=6) | CRS-CON (n=7) | CRS+Sac/Val (n=7) | |
|---|---|---|---|
| VFRF (%) | 0.0 | 13.8 ± 0.9* | 10.8 ± 1.3*† |
| VFIF (%) | 3.5 ± 0.07 | 10.6 ± 0.4* | 9.0 ± 0.5*† |
| CD (capillaries/mm2) | 2910 ± 80 | 2768 ± 124 | 2804 ± 107 |
| ODD (μm) | 8.8 ± 0.2 | 10.1 ± 0.4* | 10.6 ± 0.3* |
| MCSA (μm2) | 410 ± 10 | 565 ± 17* | 538 ± 18* |
| VFKFtotal | 0.31 ± 0.06 | 7.39 ± 0.47* | 2.47 ± 0.22*† |
Sac/Val=sacubitril/valsartan; VFRF=volume fraction of replacement fibrosis; VFIF=volume fraction of interstitial fibrosis; CD=capillary density; ODD=oxygen diffusion distance; MCSA=myocyte cross-sectional area. VFKFtotal=Total volume fraction of kidney fibrosis.
*
=p<0.05 vs. NL;
†
=p<0.05 vs. CRS-CON.