Table 7.
32 Full factorial design layout and responses noted for NS based gel formulations
| Formulation run | X1# (%) |
X2# (%) |
R1# (cP)* |
R2# (%)* |
|---|---|---|---|---|
| N1 | −1 | −1 | 9747 ± 0.22 | 76.63 ± 1.12 |
| N2 | −1 | 0 | 9958 ± 0.13 | 75.24 ± 0.98 |
| N3 | −1 | +1 | 10,246 ± 0.18 | 73.82 ± 0.93 |
| N4 | 0 | −1 | 11,785 ± 0.23 | 70.45 ± 1.03 |
| N5 | 0 | 0 | 12,316 ± 0.11 | 69.32 ± 0.76 |
| N6 | 0 | +1 | 12,954 ± 0.16 | 68.51 ± 0.94 |
| N7 | +1 | −1 | 13,625 ± 0.27 | 66.42 ± 0.57 |
| N8 | +1 | 0 | 14,128 ± 0.21 | 65.14 ± 0.34 |
| N9 | +1 | +1 | 14,934 ± 0.19 | 63.95 ± 1.07 |
| Factors and their coded levels | Low (−1) | Medium (0) | High (+1) | |
| X1 and X2 | 0.4 | 0.5 | 0.6 | |
#X1- Concentration of gelling agent Carbopol-934; X2- Concentration of guar gum; R1- Viscosity; R2- In vitro drug release, *Mean ± SD, n = 3