Table 3.
In vivo studies of effect of papaya leaf extracts on dengue fever
| Leaf extract | Oral route of administration (dose) | Results | References |
|---|---|---|---|
| Juice | 0.2 ml, 7 d | Platelet and RBC count were significantly increased after 21 d (5.53X105/ml to 11.3 × 105/ml), (6 × 106/ml to 9 × 105/ml) in mice. | [62] |
| Juice | 25 ml, twice daily, 5 d | Significantly increased platelets, RBC, WBC and PMN in male dengue patient. | [63] |
| Ethanol (70%) | 1.1 g, twice daily, 12 d | The results showed that CPC had significant increased the platelet count (p < 0.05), maintained stability of hematocrit in the normal level, shorten hospitalization (p < 0.05) in dengue fever patients | [64] |
| Juice | 50 g, daily, 3 d | The ALOX 12 (FC = 15.00) and PTAFR (FC = 13.42) genes were highly expressed among those on the juice | [65] |
| Juice | 0.72 ml/100 g | High dose of mature leaf concentrate of C papaya in thrombocytopenic rats significantly (P < 0.05) increased platelets by 76.5%, WBC by 30.51% and RBCs by 9.08%, when compared with controls | [66] |
| juice | 1000 mg/kg BW | Significantly downregulated 8 inflammatory cytokine genes CL6/MRP-1, CCL8/MCP-2, CCL12/MCP-5, CCL17/TARC, IL1R1, IL1RN/IL1Ra, NAMPT/PBEF1 and PF4/CXCL4 were observed in the liver of infected AG129 mice. | [30] |