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. 2020 Nov 30;10:144. doi: 10.1186/s13550-020-00733-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Anatomical localisation of areas of decreased metabolic activity in AD patients (p < 0.001, uncorrected, k > 1.86 cm³) for SQA using digital controls (left panel), SQA using conventional controls (middle panel), and the significant additional hypometabolic areas obtained with SQA using digital controls compared to SQA using conventional controls (right panel), projected onto 3D volume rendering, spatially normalised and smoothed into the standard SPM template (T-voxel threshold value of 3.3)