Table 5.

Individual or combined component of VMS and risk of CVD

	Vasomotor symptoms (VMS)	CVD				CHD				Stroke
		No. of CVD events	No. of cases per 1000 person-years	Adjusted hazard ratio (95% CI)		No. of CHD events	No. of cases per 1000 person-years	Adjusted hazard ratio (95% CI)		No. of stroke events	No. of cases per 1000 person-years	Adjusted hazard ratio (95% CI)
Frequency (ALSWH, SWAN)	No VMS	774	5.7	1.00		674	4.9	1.00		176	1.3	1.00
	Only had night sweats	155	5.0	1.16 (0.86, 1.56)		137	4.4	1.14 (0.83, 1.57)		34	1.1	1.15 (0.62, 2.11)
	Only had hot flushes	63	7.6	0.87 (0.71, 1.06)		55	6.6	0.89 (0.72, 1.09)		11	1.3	0.66 (0.42, 1.05)
	Both had hot flushes and night sweats	415	6.8	1.17 (1.03, 1.33)		362	5.9	1.16 (1.01, 1.32)		100	1.6	1.15 (0.89, 1.49)
Severity (NSHD, NCDS, HOW, WHITEHALL)	No VMS	393	8.5	1.00		355	7.6	1.00		49	1.2	1.00
	Only had night sweats	50	6.2	1.32 (0.84, 2.07)		47	5.8	1.42 (0.89, 2.26)		5	1.0	0.44 (0.06, 3.29)
	Only had hot flushes	38	10.6	1.33 (0.94, 1.88)		37	10.3	1.46 (1.02, 2.07)		1	0.4	0.57 (0.13, 2.45)
	Both had hot flushes and night sweats	117	7.6	1.55 (1.24, 1.94)		110	7.1	1.58 (1.25, 2.01)		10	1.3	1.36 (0.72, 2.59)
Frequency or severity	No VMS	1167	6.4	1.00		1029	5.6	1.00		225	1.3	1.00
	Only had night sweats	205	5.3	1.27 (1.00, 1.63)		184	4.7	1.29 (0.99, 1.67)		39	1.1	1.07 (0.60, 1.91)
	Only had hot flushes	101	8.5	0.96 (0.81, 1.14)		92	7.7	1.00 (0.83, 1.20)		12	1.1	0.66 (0.43, 1.02)
	Both had hot flushes and night sweats	532	6.9	1.24 (1.11, 1.38)		472	6.1	1.23 (1.10, 1.39)		110	1.6	1.18 (0.93, 1.50)

All HRs were adjusted for age at beginning of the interval, race/ethnicity, education, body mass index, smoking status, hypertension status, menopausal hormone therapy status, and menopausal status.

Abbreviations: CVD, cardiovascular disease; CHD, coronary heart disease.