Figure 1. Influx of Ly6G^Pos cells into the pulmonary compartment correlates with Mtb burden, inflammatory cytokines, and disease severity.

a Mouse models of increasingly severe disease (left to right), with representative scatterplots of CD11b^High Ly6G^Pos pulmonary cells at 28 days PI, and quantified (far right) as percent Ly6G^pos cells by recovered CFUs in the lung of each individual mouse. b Representative scatterplots (left) and quantification (right) of CD11b^High Ly6G^High neutrophils (top right), CD11b^High Ly6G^Mid granulocytes (middle right), and CD11b^High Ly6G^Neg monocytes/macrophages (bottom right) in Bl6 WT or Nos2^−/− mice at the indicated time points PI. N = 4 mice per group and error bars represent standard deviation between biological replicates within each group. c Multiplex analysis of the indicated cytokines and chemokines in the lungs of Bl6 WT or Nos2^−/− mice at the indicated time points PI. Heatmap represents the average pg/mL of detected cytokine/chemokine from 4 mice per group scaled by row.