Table 3:
Univariable relationship between somatic mutations with 5-year lung cancer specific survival
| All (N=82) | LUAD (N=36) | LUSC (N=39) | ||||
|---|---|---|---|---|---|---|
| Gene | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
| STK11 status | ||||||
| Wild Type STK11 | Reference | Reference | Reference | |||
| Mutant STK11 | 0.60 (0.21-1.70) | 0.33 | 0.82 (0.22-3.02) | 0.76 | 0.65 (0.09-4.86) | 0.67 |
| RB1 status | ||||||
| Wild Type RB1 | Reference | Reference | Reference | |||
| Mutant RB1 | 0.48 (0.17-1.36) | 0.17 | 0.31 (0.04-2.44) | 0.27 | 0.71 (0.20-2.44) | 0.58 |
| CDKN2A status | ||||||
| Wild Type CDKN2A | Reference | Reference | Reference | |||
| Mutant CDKN2A | 1.64 (0.64-4.23) | 0.30 | NA | NA | 2.93 (1.04-8.28) | 0.04 |
| PIK3CG status | ||||||
| Wild Type PIK3CG | Reference | Reference | Reference | |||
| Mutant PIK3CG | 0.68 (0.27-1.76) | 0.43 | 0.35 (0.04-2.7) | 0.31 | 0.76 (0.18-3.33) | 0.72 |
| PTPRT status | ||||||
| Wild Type PTPRT | Reference | Reference | Reference | |||
| Mutant PTPRT | 0.81 (0.38-1.73) | 0.59 | 0.38 (0.08-1.173) | 0.21 | 1.06 (0.35-3.23) | 0.92 |
| JAK2 Status | ||||||
| Wild Type JAK2 | Reference | Reference | Reference | |||
| Mutant JAK2 | 1.33 (0.63-2.84) | 0.46 | 0.57 (0.12-2.61) | 0.47 | 2.40 0.90-6.40 | 0.08 |
| LRP1B status | ||||||
| Wild Type LRP1B | Reference | Reference | Reference | |||
| Mutant LRP1B | 0.80 (0.41-1.56) | 0.51 | 0.45 (0.14-1.43) | 0.18 | 1.12 (0.43-3.40) | 0.72 |
| SPTA1 status | ||||||
| Wild Type SPTA1 | Reference | Reference | Reference | |||
| Mutant SPTA1 | 0.72 (0.37-1.39) | 0.33 | 0.63 (0.20-1.96) | 0.43 | 0.70 (0.26-1.85) | 0.47 |
| NAV3 status | ||||||
| Wild Type NAV3 | Reference | Reference | Reference | |||
| Mutant NAV3 | 0.91 (0.47-1.76) | 0.78 | 0.49 (0.13-1.80) | 0.28 | 0.78 (0.29-2.08) | 0.62 |
| COL11A1 status | ||||||
| Wild Type COL11A1 | Reference | Reference | Reference | |||
| Mutant COL11A1 | 0.90 (0.47-1.75) | 0.76 | 0.49 (0.15-1.62) | 0.24 | 0.96 (0.37-2.49) | 0.94 |
| SI status | ||||||
| Wild Type SI | Reference | Reference | Reference | |||
| Mutant SI | 0.69 (0.36-1.32) | 0.26 | 0.40 (0.12-1.33) | 0.14 | 0.93 (0.37-2.34) | 0.88 |
| ASXL3 status | ||||||
| Wild Type ASXL3 | Reference | Reference | Reference | |||
| Mutant ASXL3 | 1.70 (0.85-3.40) | 0.14 | 0.48 (0.10-2.19) | 0.34 | 4.49 (1.69-11.95) | 0.0026 |
| ZNF536 status | ||||||
| Wild Type ZNF536 | Reference | Reference | Reference | |||
| Mutant ZNF536 | 1.52 (0.77-3.02) | 0.23 | 0.91 (0.25-3.35) | 0.88 | 1.79 (0.67-4.81) | 0.25 |
HR denotes hazard ratio, CI denotes confidence interval