. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: J Affect Disord. 2020 Sep 23;278:542–555. doi: 10.1016/j.jad.2020.09.071

Table 2.

Summary of meta-analysis results (overall).

Outcome	Random effects model	Corrected for publication bias	z	p-value	I²	k
Response	RR = 2.0382 [1.5748; 2.6380]	RR = 1.4209 [1.0950; 1.8438]	5.41	< 0.0001	62.7%	31
Remission	RR = 2.0029 [1.5005; 2.6735]	RR = 1.5521 [1.1472; 2.1000]	4.71	< 0.0001	38.5%	24
Score	SMD = −1.1430 [−1.4613; −0.8247]	SMD = −0.4832 [−0.8453; −0.1212]	−7.04	< 0.0001	89.8%	31
Suicidality	SMD = −0.3867 [−0.7082; −0.0653]	SMD = −0.5034 [−0.8180; −0.1888]	−2.36	0.0184	71.3	12
Completion	RR = 0.9929 [0.9681; 1.0182]	RR = 0.9876 [0.9576; 1.0185]	−0.56	0.5773	14.0	31
Dropouts	RR = 0.9664 [0.7234; 1.2911]	RR = 0.9229 [0.6864; 1.2410]	−0.23	0.8173	40.5	24
Adverse events	RR = 1.8703 [1.0271; 3.4076]	RR = 2.0087 [1.1150; 3.6188]	2.05	0.0406	0.0	14

RR = rate ratio; SMD = standardized mean difference; z = z-score (on normal distribution); I² = measure of heterogeneity (closer to 100.0 indicates higher heterogeneity); k = number of trials involved in the sub analysis.