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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Nat Protoc. 2020 Oct 26;15(12):3777–3787. doi: 10.1038/s41596-020-00403-2

Figure 2. Schematics of COVID-19 GEMM designs, category 2: Knocking-in CRE-activatable or tetracycline-inducible expression cassettes into safe-harbor loci by re-engineering existing reporter or inducer mouse lines.

Figure 2.

(A) Constitutive (B) CRE-activatable and (C) tetracycline-inducible designs (GEMMs #16 to #21). These models can be generated by re-engineering existing reporter and tetracycline-inducible models. P2A: a self-cleavable viral peptide used for expressing two fusion proteins. IRES: Internal Ribosomal Entry Site.