Fig. 5. Properties of AuNPs/PEG.
a UV–Vis spectra of AuNPs15/c-PEG3k immediately after, 7 d after, and 14 d after the addition of a tenfold-concentrated PBS solution. Rel. Abs was 81% after 7 d and 60% after 14 d. b Time course of Rel. Abs of AuNPs/c-PEG3k in a physiological condition of pH 7.4 and 150 mM of NaCl. The diameter of AuNPs was 5–100 nm. c Time course of Rel. Abs of AuNPs5 in the physiological condition in the presence of HO–PEG5k–OH or c-PEG5k with various concentrations. HO–PEG5k–OH, 0.25 wt% (blue square); 2.5 wt% (blue circle); 10 wt% (blue cross). c-PEG5k, 0.025 wt% (red triangle); 0.25 wt% (red square); 2.5 wt% (red circle). d c-PEG layer thickness and ζ-potential for AuNPs15/c-PEG3k with various concentration of c-PEG3k. Biodistribution of Au in e blood and f tumor of mice after 10 and 60 min of the injection of AuNPs5/No PEG, AuNPs5/MeO–PEG3k–OMe, and AuNPs5/c-PEG3k. Data represent mean ± s.e. from three independent experiments performed in triplicate. *p < 0.05; N.S. = not significant. Source data for (e, f) are provided as a Source data file.