Table 2.
Clinicopathologic features of patients with Intrahepatic cholangiocarcinoma
| Item | CONUT <3 (n = 112) | CONUT ≥3 (n = 57) | p |
|---|---|---|---|
| Age | 57.19 ± 9.36 | 59.47 ± 8.12 | 0.103 |
| Gender (male:female) | 67:44 | 28:28 | 0.251 |
| History of long-term alcohol consumption | 28 (25.0) | 11 (19.3) | 0.406 |
| History of biliary stones | 16 (14.3) | 12 (21.1) | 0.263 |
| HBsAg (+) | 28 (25.0) | 7 (12.3) | 0.069 |
| Liver cirrhosis | 49 (43.8) | 13 (23.2) | 0.009* |
| Preoperative therapy | 7 (6.3) | 4 (7.0) | 0.848 |
| Tumor margin (<1 mm) | 42 (37.5) | 30 (52.6) | 0.094 |
| Mass-forming tumor | 111 (99.1) | 54 (94.7) | 0.258 |
| Centre-located tumor | 60 (53.6) | 25 (43.9) | 0.233 |
| Poorly differentiated | 62 (55.4) | 33 (57.9) | 0.867 |
| Multiple tumors | 19 (17.0) | 14 (24.6) | 0.303 |
| Tumor size (cm) | 4.860 ± 2.1814 | 6.779 ± 2.6321 | 0.000* |
| TNM stage: T1 | 58 (51.8) | 21 (36.8) | 0.066 |
| TNM stage: T2 | 31 (27.7) | 16 (28.1) | 0.957 |
| Positive lymph node metastasis (TNM stage: N1) | 18 (16.1) | 26 (45.6) | 0.000* |
| Microvascular invasion | 39 (34.8) | 22 (38.6) | 0.734 |
| Capsular invasion | 80 (71.4) | 45 (78.9) | 0.244 |
| Perineural invasion | 29 (25.8) | 27 (47.3) | 0.006* |
| Postoperative therapy before recurrence | 41 (36.7) | 23 (40.4) | 0.489 |
| Preoperative CEA (ng/ml) | 6.60 ± 35.28 | 18.69 ± 50.15 | 0.109 |
| Preoperative CA199 (U/ml) | 501.79 ± 3,183.57 | 1,792.14 ± 2,874.04 | 0.015* |
| Preoperative GGT (U/L) | 101.17 ± 191.25 | 118.18 ± 173.92 | 0.574 |
| Preoperative ALP (U/L) | 98.13 ± 101.70 | 123.56 ± 80.12 | 0.102 |
| Preoperative TBIL (µmol/L) | 16.16 ± 20.61 | 19.06 ± 52.88 | 0.611 |
| Preoperative ALT (U/L) | 34.45 ± 52.44 | 34.53 ± 68.21 | 0.993 |
| Preoperative AST (U/L) | 29.07 ± 29.02 | 29.46 ± 30.91 | 0.938 |
Data are the mean with SD in parentheses for continuous variables, with p values from t tests; data are numbers with percentages in parentheses for categorical variables, with p values from chi-square test, *significant at p<0.05.