Fig. 3.

Cancellation of SOCS after H. pylori and restoring of SOCS1 with WPE. (A) Changes of SOCS1 mRNA with H. pylori infection RT-PCR for SOCS1 (left) and changes of SOCS mRNA after WPE (right). (B) Western blot of SOCS1 after WPE Statistically significant increases of SOCS1 at 2 h of WPE. *p<0.01. (C) STAT3 activation and the expression of c-Myc between Mock-transfected and siSOCS1 transfected RGM-1 WPE significantly decreased H. pylori-increased either p-STAT^Tyr705 or c-Myc in Mock transfected RGM-1 cells, but these changes were abolished in siSOCS1-transfected cells.