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Inhibition of [3H]methoxy-PEPy binding to HEK293A-mGlu5-low cell membranes by mGlu5 NAMs. Data are means ± S.E.M. from three independent experiments performed in duplicate. All compounds completely displaced [3H]methoxy-PEPy binding. Veh. denotes vehicle (1% DMSO), which was kept constant for all concentrations of NAMs. Chemical structures for each ligand are shown, showing the chemical diversity sampled within this study. Error bars not shown lie within the dimensions of the symbol.
