FIGURE 1.

Autophagy-lysosomal pathway (ALP). The lysosome is a key cellular organelle for the degradation of proteins maintaining a balance between synthesis and clearance. Three pathways—macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy—converge on this central hub to deliver cargo for degradation. The lysosome is a central mechanism by which the production of aSyn in the brain is controlled (see text for details). LAMP-2A, Lysosome-associated membrane glycoprotein 2; HSC70, heat shock cognate 70; CtsL, Cathepsin L; CtsD, Cathepsin D; CtsB, Cathepsin B; GCase, Glucocerebrosidase.