Table 2.
Metabolic pathways utilized by activated dendritic cells.
| Immune cell | Metabolic pathway | Metabolic reprogramming | Relevance of metabolic pathway to cellular function | Model | References |
|---|---|---|---|---|---|
| Activated DCs | Glycolysis | ⇑ | Required for activation | PAMPs-stimulated human monocyte-derived DCs | (173) |
| TLR agonist-stimulated DCs | (174) | ||||
| Required for migration | In vitro stimulated bone marrow-derived DCs and splenic DCs | (175) | |||
| Oxidative phosphorylation | - | PAMPs-stimulated human monocyte-derived DCs | (173) | ||
| ⇓ | (176) | ||||
| Pentose phosphate pathway | ⇑ | Required for the enhanced synthesis of fatty acids | (177) | ||
| TCA cycle | Truncated | Production of NO and ROS | (176) | ||
| Lipogenesis | ⇑ | Required for activation | TLR agonist-stimulated DCs | (174) |
⇑, high metabolic rate; ⇓, low metabolic rate; -, no change in metabolic rate.