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. 2020 Nov 17;7:509. doi: 10.3389/fmed.2020.00509

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Copyright © 2020 Zhang, Wang, Zhao, Jiang, Gong, Jiang, Xu, He, Li and Jing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma superoxide dismutase (SOD) activity in patients with idiopathic pulmonary arterial hypertension (IPAH), control subjects, patients with BMPR2 mutation (BMPR2 mut), and those with wild-type BMPR2 (BMPR2 wt), associated with WHO functional class. (A) The plasma Cu/Zn level was significantly decreased in patients with IPAH compared to that in the control subjects. (B) The Mn-SOD activity was significantly lower in patients with IPAH compared to that in the control subjects. (C) The Ec-SOD activities in patients with IPAH were significantly lower compared to those in the control subjects. The Ec-SOD activity in patients of the BMPR2 mut group was statistically decreased compared to that in patients of the BMPR2 wt group. The line through the center of the boxes represents the median. BMPR 2, bone morphogenetic protein receptor type 2; Cu/Zn-SOD, copper–zinc superoxide dismutase; Mn-SOD, manganese superoxide dismutase; Ec-SOD, extracellular form of Cu/Zn superoxide dismutase.