Figure 3.

Cox proportional hazards model of factors associated with survival in idiopathic pulmonary arterial hypertension (univariate and multivariate analyses). The lower Ec-SOD and the higher PVR remained as significant predictors of adverse outcomes. The asterisk indicates identification by the receiver operating characteristic analysis curve-derived cutoff value. BMPR 2, bone morphogenetic protein receptor type 2; CO, cardiac output; Cu/Zn-SOD, copper–zinc superoxide dismutase; Ec-SOD, extracellular form of Cu/Zn superoxide dismutase; Mn-SOD, manganese superoxide dismutase; mPAP, mean pulmonary arterial pressure; mRAP, mean right atrial pressure; 6MWD, 6-min walking distance; PVR, pulmonary vascular resistance; SvO₂, mixed venous oxygen saturation.