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Extracellular form of Cu/Zn superoxide dismutase (Ec-SOD) activity in relation to other markers for an adverse prognosis according to (A) receiver operation characteristic analyses and (B) survival curves for the baseline cutoff plasma Ec-SOD activity in patients with idiopathic pulmonary arterial hypertension, adjusted by age and female gender. The best Ec-SOD cutoff level for predicting outcome was 83 U/L. Survival was significantly better in patients with Ec-SOD activity >83 U/L.
