TABLE 3.
Comparisons of clinical and microbiological characteristics between FS and FNS, FNS CC2 and Other FNS C. tropicalis infections, Wuhan.
| Characteristic | FS Infection (n = 49) | FNS Infection (n = 35) | P-value | FNS CC2 Infection (n = 13) | Other FNS Infection (n = 22) | P-value |
| Demographics | ||||||
| Age, y, median (IQR) | 55.0 (37.0–67.0) | 57.0 (44.5–76.5) | 0.19 | 63.0 (56.0–82.0) | 55.0 (44.3–73.8) | 0.35 |
| Sex n (%) | 0.48 | 0.72 | ||||
| M | 22 (44.9) | 13 (37.1) | 4 (30.8) | 9 (40.9) | ||
| F | 27 (55.1) | 22 (62.9) | 9 (69.2) | 13 (59.1) | ||
| Comorbid conditionsan (%) | ||||||
| Heart disease | 9 (18.4) | 14 (40.0) | 0.03* | 4 (30.8) | 10 (45.5) | 0.49 |
| Lung diseases | 16 (32.7) | 17 (48.6) | 0.14 | 9 (69.2) | 8 (36.4) | 0.09 |
| Hepatobiliary/pancreatic diseases | 10 (20.4) | 10 (28.6) | 0.39 | 4 (30.8) | 6 (27.3) | 1.00 |
| Kidney disease | 10 (20.4) | 13 (37.1) | 0.09 | 6 (46.2) | 7 (31.8) | 0.48 |
| Brain diseases | 9 (18.4) | 11 (31.4) | 0.17 | 4 (30.8) | 7 (31.8) | 1.00 |
| Solid tumor | 4 (8.2) | 7 (20.0) | 0.21 | 4 (30.8) | 3 (13.6) | 0.38 |
| Diabetes | 9 (18.4) | 4 (11.4) | 0.39 | 1 (7.7) | 3 (13.6) | 1.00 |
| Hypertension | 13 (26.5) | 14 (40.0) | 0.19 | 6 (46.2) | 8 (36.4) | 0.72 |
| Gynecological disease | 15 (30.6) | 6 (17.1) | 0.16 | 2 (15.4) | 4 (18.2) | 1.00 |
| Healthcare factors n (%) | ||||||
| Solid-organ transplant | 1 (2.0) | 0 | 1.00 | 0 | 0 | – |
| Surgery | 12 (24.5) | 9 (25.7) | 0.90 | 5 (38.5) | 4 (18.2) | 0.24 |
| Mechanical ventilator | 13 (26.5) | 14 (40.0) | 0.19 | 7 (53.8) | 7 (31.8) | 0.29 |
| Indwelling urinary catheter | 18 (36.7) | 18 (51.4) | 0.18 | 8 (61.5) | 10 (45.5) | 0.49 |
| Central venous catheter | 12 (24.5) | 13 (37.1) | 0.21 | 6 (46.2) | 7 (31.8) | 0.48 |
| Antifungal drug exposure | 6 (12.2) | 11 (31.4) | 0.03* | 4 (30.8) | 7 (31.8) | 1.00 |
| Antimicrobial drug exposure | 38 (77.6) | 28 (80.0) | 0.79 | 11 (84.6) | 17 (77.3) | 0.69 |
| Primary infection sites n (%) | ||||||
| Bloodstream infection | 7 (14.3) | 6 (17.1) | 0.72 | 2 (15.4) | 4 (18.2) | 1.00 |
| Visceral infection | 3 (6.1) | 2 (5.7) | 1.00 | 1 (7.7) | 1 (4.5) | 1.00 |
| Urinary tract infection | 20 (40.8) | 20 (57.2) | 0.14 | 8 (61.5) | 12 (54.6) | 0.74 |
| Respiratory tract infection | 3 (6.1) | 1 (2.9) | 0.86 | 1 (7.7) | 0 | 0.37 |
| Reproductive tract infection | 16 (32.7) | 6 (17.1) | 0.11 | 1 (7.7) | 5 (22.7) | 0.38 |
| Wards n (%) | ||||||
| ICU/RICU | 8 (16.3) | 7 (20.0) | 0.67 | 2 (15.4) | 5 (22.7) | 0.69 |
| Gynecology/Reproductive | 16 (32.7) | 7 (20.0) | 0.20 | 1 (7.7) | 6 (27.3) | 0.22 |
| Surgeryb | 19 (38.8) | 9 (25.7) | 0.21 | 4 (30.8) | 5 (22.7) | 0.70 |
| Medicalc | 6 (12.2) | 12 (34.3) | 0.02* | 6 (46.1) | 6 (27.3) | 0.29 |
| Death n (%) | ||||||
| All | 6 (12.2) | 10 (28.6) | 0.06 | 3 (23.1) | 7 (31.8) | 0.71 |
| With pulmonary candidiasisd | 1 (33.3) | 1 (100.0) | 1.00 | 1 (100.0) | 0 | − |
| With candidemiae | 1 (14.3) | 3 (50.0) | 0.27 | 1 (50.0) | 2 (50.0) | 1.00 |
| With candidiuriaf | 4 (20.0) | 6 (30.0) | 0.47 | 1 (12.5) | 5 (41.7) | 0.33 |
aAll systemic diseases were not graded, including mild-severe infection, mild organ dysfunction-severe organ failure.
bSurgery wards: including Urology ward, Pancreatic ward, Hepatobiliary ward, Cardiovascular Surgery ward, Neurosurgery ward, Transplantation ward, and Interventional ward.
cMedical wards: including Geriatric ward, Oncology ward, neurology ward, Cardiovascular Medicine ward, Endocrinology ward, Hematology ward, and Nephrology ward.
dWith pulmonary candidiasis: A total of 4 cases. FS Infection (n = 3), FNS Infection (n = 1); FNS CC2 Infection (n = 1), Other FNS Infection (n = 0). There was only 1 case of pulmonary Candida infection with FNS C. tropicalis (in CC2), which could not be compared in groups (FNS CC2 Infection group and Other FNS Infection group), so the P-value was shown as “−”.
eWith candidemia: A total of 13 cases. FS Infection (n = 7), FNS Infection (n = 6); FNS CC2 Infection (n = 2), Other FNS Infection (n = 4).
fWith candidiuria: A total of 40 cases. FS Infection (n = 20), FNS Infection (n = 20); FNS CC2 Infection (n = 8), Other FNS Infection (n = 12).
*P<0.05, the difference was statistically significant.