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Apremilast modulated naïve CD4+ T-cells in vitro. Cells isolated from the DLNs stimulated with IRBP1-20 for 3 days with or without apremilast were analyzed by flow cytometry. (A–I) Apremilast suppressed the frequency and number of IL17A-, IFNγ-, and TNFα-producing cells. (J–L) Apremilast upregulated the proportion and population of CD4+CD25+Foxp3+ T-cells. Data expressed as mean±SD, **P < 0.01, ***P < 0.001, N = 6.
