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. 2020 Nov 17;11:581673. doi: 10.3389/fimmu.2020.581673

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Copyright © 2020 Chen, Li, Li, Su, Xie, Pan, Chen and Liang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apremilast failed to rebuild the imbalance between Treg/Teff of EAU co-stimulated with SC79. Cells from the DLNs of the EAU group were cultured in IRBP_1-20 and apremilast with or without SC79 (16 mg/ml). (A–I) The proportion and population of IL17A-, IFNγ-, and TNFα-producing CD4+ T-cells in the two groups. (J–L) The proportion and population of CD4+CD25+Foxp3+ T-cells of the two groups. Data expressed as mean±SD, *P < 0.05, **P < 0.01, ***P < 0.001, N = 6.