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. 2020 Nov 17;8:587285. doi: 10.3389/fped.2020.587285

Table 3.

Literature on esophageal atresia (EA) repair in very low birth weight (VLBW)/extremely low birth weight (ELBW).

Author Year Period n1 Weight Primary Staged EA Type Aim of the study Conclusion
Schmidt et al. (15) 2017 2002–2016 11 4 ELBW
7 VLBW
(24 > 1,500 g)
4
7
24
Gross C Compare outcome after primary open repair in VLBW/ELBW with BW > 1,500 g Complications are unrelated to bodyweight
Hannon et al. (16) 2016 1993–2015 9 ELBW
(m2 = 815 g)
2 7 All Outcome of EA repair in ELBW 56% survival, due to immaturity; Gross A with staged repair, 100% survival
Zani et al. (17) 2016 2000–2014 7 ELBW
(m = 930 g)
1 6 All Outcome of EA repair in ELBW Complications associated with prematurity
Margain et al. (18) 2014 2012–2013 3 ELBW
(m = 690 g)
3 Gross C Outcome of EA repair in ELBW treated with LEB3 and delayed repair LEB enables delayed repair (> 2100g)
Ito et al. (19) 2013 1 ELBW
(471 g)
1 Gross C Case report: Delayed primary repair after EB4 Complications associated with prematurity
EA repair was performed too late
Petrosyan et al. (20) 2009 1987–2008 25 VLBW
(m = 1380 g)
16 9 All Comparison between primary and staged repair in EA Significantly more complications
after primary repair
Seitz et al. (21) 2006 2002–2004 4 VLBW
(m = 920 g)
4 Gross C Outcome of EA in VLBW Primary repair is technically feasible,
AI and AS in 25%
Chahine and Ricketts (5) 2000 1981–1999 10 VLBW
(m = 1160 g)
1 9 all Outcome of EA in VLBW 10% died after sepsis caused by AI
GER and fundo in 62.5%
Driver et al. (22) 1997 1 ELBW
(740 g)
1 Gross C Case report Good outcome due to
improved NICU treatment
Alexander et al. (23) 1993 1966–1986 21 <2,000 g
(1590 g)
4 17 all Comparison between primary and staged repair in EA Staged repair incurred a lesser morbidity
Schaarschmidt et al. (24) 1992 1 ELBW
(445 g)
1 Delayed primary repair without ligation of TEF5, Case report No operation-associated complications
Todd et al. (25) 1990 1 ELBW
(700g)
1 Outcome of EA (IIIb) and delayed repair after LEB3, Case report Mechanical ventilation after LEB3 dilatates the distal esophagus

Overview of the literature regarding the repair of EA with or without TEF in patients born with exclusively ELBW and VLBW, without the claim of completeness.

1

n, number of patients.

2

m, median.

3

LEB, lower esophageal banding.

4

EB, esophageal banding.

5

TEF, tracheo-esophageal fistula.