Table 3.
Biochemical Profile According to APOE Alleles
| Biochemical Variables | Reference Values | ε2 | ε3 | ε4 | p value |
|---|---|---|---|---|---|
| Total cholesterol (mg/dL) | <200 | 162.6±35.8 | 183.7±41.6 | 183.1±31.6 | 0.180 |
| HDL-c (mg/dL) | >50 | 47.5±11.9 | 48.9±14.3 | 45.6±14.1 | 0.375 |
| Non-HDL-c (mg/dL) | <130 | 115.2±33.8 | 134.9±39.6 | 137.2±26.9 | 0.153 |
| LDL-c (mg/dL) | <100 | 85.4±25.1 | 102.4±32.7 | 109.5±26.8 | 0.050 |
| Triglycerides (mg/dL) | <150 | 148.4±62.0 | 163.7±90.3 | 154.4±74.5 | 0.702 |
| Glucose (mg/dL) | <110 | 119.9±25.5 | 161.5±71.8 | 134.2±45.9 | 0.008a |
| TyG index | <8.3 | 8.6±0.8 | 8.9±0.7 | 8.9±0.6 | 0.466 |
| HbA1c (%) | <6.5 | 6.6±0.6 | 7.8±2.0 | 7.2±1.7 | 0.030a |
| ALT (IU/L) | <30 | 40.8±18.0 | 38.9±19.3 | 34.7±12.7 | 0.434 |
| AST (IU/L) | <30 | 28.5±13.1 | 32.7±15.1 | 27.0±8.6 | 0.085 |
Notes: Values are presented as means ± standard deviations. aBy post hoc tests: Glucose: ε3 vs ε2, p <0.001; ε3 vs ε4, p=0.007. HbA1c: ε3 vs ε2, p <0.001. The one-way ANOVA test for continuous variables was the statistical method.
Abbreviations: HDL-c, high-density lipoprotein cholesterol; Non-HDL-c, non-high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; TyG index, triglycerides-glucose index; HbA1c, glycated hemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase.