Table 2.
Matched Baseline Patient Characteristics
| BDP/FF vs FP/SAL | BDP/FF vs BUD/FF | ||||||
|---|---|---|---|---|---|---|---|
| BDP/FF n=537 |
FP/SAL n=537 |
SMD | BDP/FF n=540 |
BUD/FF n=540 |
SMD | ||
| Sex | Male | 292 (54.4) | 313 (58.3) | 7.9 | 295 (54.6) | 293 (54.3) | 0.7 |
| Age (years)a | ≥35–<45 | 7 (1.3) | 7 (1.3) | 0 | 10 (1.9) | 10 (1.9) | 0 |
| ≥45–<55 | 39 (7.3) | 39 (7.3) | 41 (7.6) | 41 (7.6) | |||
| ≥55–<65 | 115 (21.4) | 115 (21.4) | 113 (20.9) | 113 (20.9) | |||
| ≥65 | 376 (70.0) | 376 (70.0) | 376 (69.6) | 376 (69.6) | |||
| BMI (kg/m2) | n (% not missing) | 537 (100) | 536 (99.8) | 5.5 | 540 (100) | 538 (99.6) | 9.6 |
| <18.5 | 30 (5.6) | 31 (5.8) | 30 (5.6) | 30 (5.6) | |||
| ≥18.5–<25 | 180 (33.5) | 191 (35.6) | 179 (33.1) | 200 (37.2) | |||
| ≥25–<30 | 192 (35.8) | 179 (33.4) | 193 (35.7) | 171 (31.8) | |||
| ≥30 | 135 (25.1) | 135 (25.2) | 138 (25.6) | 137 (25.5) | |||
| Patient-reported smoking statusa | Nonsmoker | 19 (3.5) | 19 (3.5) | 0 | 17 (3.1) | 17 (3.1) | 0 |
| Current smoker | 224 (41.7) | 224 (41.7) | 227 (42.0) | 227 (42.0) | |||
| Ex-smoker | 294 (54.7) | 294 (54.7) | 296 (54.8) | 296 (54.8) | |||
| Baseline SABA prescription(s) | 0 | 132 (24.6) | 90 (16.8) | 23.9 | 132 (24.4) | 96 (17.8) | 18.9 |
| 1 | 38 (7.1) | 36 (6.7) | 38 (7.0) | 43 (8.0) | |||
| 2–4 | 82 (15.3) | 110 (20.5) | 81 (15.0) | 93 (17.2) | |||
| 5–10 | 141 (26.3) | 169 (31.5) | 145 (26.9) | 173 (32.0) | |||
| ≥11 | 144 (26.8) | 132 (24.6) | 144 (26.7) | 135 (25.0) | |||
| SAMA/SABA combination prescriptions | Yes | 7 (1.3) | 53 (9.9) | 38.0 | 7 (1.3) | 41 (7.6) | 30.9 |
| ICS combination-inhaler prescriptions | 0 | 187 (34.8) | 173 (32.2) | 10.9 | 184 (34.1) | 242 (44.8) | 27.7 |
| 1 | 26 (4.8) | 23 (4.3) | 26 (4.8) | 29 (5.4) | |||
| 2–4 | 51 (9.5) | 59 (11.0) | 53 (9.8) | 65 (12.0) | |||
| 5–10 | 146 (27.2) | 135 (25.1) | 147 (27.2) | 110 (20.4) | |||
| ≥11 | 127 (23.6) | 147 (27.4) | 130 (24.1) | 94 (17.4) | |||
| Total ICS dosage (µg BDP equivalent) | 0–249 | 235 (43.8) | 221 (41.2) | 7.1 | 235 (43.5) | 275 (51.0) | 22.0 |
| 250–499 | 148 (27.6) | 145 (27.0) | 149 (27.6) | 158 (29.3) | |||
| 500+ | 154 (28.7) | 171 (31.8) | 156 (28.9) | 106(19.7) | |||
| LAMA prescriptions | Yes | 340 (63.3) | 323 (60.1) | 6.5 | 342 (63.3) | 285 (52.8) | 21.5 |
| LABA prescriptions | Yes | 63 (11.7) | 79 (14.7) | 8.8 | 64 (11.9) | 127 (23.5) | 30.9 |
| Maintenance OCS | Yes | 36 (6.7) | 25 (4.7) | 8.9 | 37 (6.9) | 22 (4.1) | 12.2 |
| Asthma diagnosis everb | Yes | 218 (40.6) | 197 (36.7) | 8.0 | 220 (40.7) | 230 (42.6) | 3.8 |
| Active anxiety/depression diagnosis | Yes | 134 (25.0) | 123 (22.9) | 4.8 | 135 (25.0) | 105 (19.4) | 13.4 |
| Charlson Comorbidity Index | 0–2 | 343 (63.9) | 347 (64.6) | 2.2 | 345 (63.9) | 349 (64.6) | 9.1 |
| 3–4 | 134 (25.0) | 129 (24.0) | 135 (25.0) | 145 (26.9) | |||
| 5+ | 60 (11.2) | 61 (11.4) | 60 (11.1) | 46 (8.5) | |||
| Baseline moderate/severe COPD exacerbationsa,c | 0 | 46 (8.6) | 46 (8.6) | 0 | 48 (8.9) | 48 (8.9) | 0 |
| 1 | 159 (29.6) | 159 (29.6) | 162 (30.0) | 162 (30.0) | |||
| 2 | 139 (25.9) | 139 (25.9) | 138 (25.6) | 138 (25.6) | |||
| 3 | 75 (14.0) | 75 (14.0) | 75 (13.9) | 75 (13.9) | |||
| 4+ | 118 (22.0) | 118 (22.0) | 117 (21.7) | 117 (21.7) | |||
| Lowest percentage predicted FEV1a | <20% | 24 (4.5) | 24 (4.5) | 0 | 24 (4.4) | 24 (4.4) | 0 |
| 20%–<30% | 98 (18.2) | 98 (18.2) | 96 (17.8) | 96 (17.8) | |||
| 30%–<40% | 159 (29.6) | 159 (29.6) | 161 (29.8) | 161 (29.8) | |||
| 40% –<55% | 256 (47.7) | 256 (47.7) | 259 (48.0) | 259 (48.0) | |||
| mMRC score | n (% not missing) | 317 (59.0) | 310 (57.7) | 19.9 | 315 (58.3) | 267 (49.4) | 17.2 |
| mMRC 0 | 37 (11.7) | 23 (7.4) | 37 (11.7) | 21 (7.9) | |||
| mMRC 1 | 105 (33.1) | 121 (39.0) | 106 (33.7) | 101 (37.8) | |||
| mMRC 2 | 95 (30.0) | 100 (32.3) | 94 (29.8) | 76 (28.5) | |||
| mMRC 3 | 66 (20.8) | 52 (16.8) | 64 (20.3) | 61 (22.8) | |||
| mMRC 4 | 14 (4.4) | 14 (4.5) | 14 (4.4) | 8 (3.0) | |||
Notes: Numbers presented as n (%). SMD values >10 (indicating sufficient imbalance between comparison groups) are emphasized in bold. aMatching variable. bBased on presence of QOF diagnosis code for asthma. cOccurrence of any one of: 1) COPD-related unscheduled hospital admission/A&E attendance, 2) an acute course of oral steroid, or 3) antibiotics prescribed with lower respiratory consultation.
Abbreviations: SMD, standardised mean difference; SABA, short-acting β-agonist; SAMA, short-acting muscarinic antagonist; LAMA, long-acting muscarinic antagonist; LABA, long-acting β-agonist; OCS, oral corticosteroid.