Figure 1.

PC4 is upregulated in PDAC and is negatively correlated with the prognosis of patients. (A) PC4 mRNA expression levels in PAAD tissues (T) and normal tissues (N) from the GEPIA database. *P < 0.05. (B) Immunohistochemical staining of PC4 protein in 81 sets of PDAC tissues, adjacent tissues and normal tissues. (C) PC4 expression as assessed by immunohistochemistry in PDAC of different pathological grades. The percentage of PC4-positive cells increased with the pathological grade. (D) Comparison of the average PC4 expression staining scores on TMA slides. (E) Overall survival of patients with PDAC based on PC4 protein expression using a Kaplan–Meier analysis (n = 81, P < 0.001). (F) Analysis of the relationship between PC4 mRNA expression and overall survival in PAAD patients from TCGA database. * P<0.05, **P<0.01, **** P<0.0001.