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. 2020 Nov 25;15:2633105520975412. doi: 10.1177/2633105520975412

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — High-dose sirolimus did not reduce binge-like ethanol intake or BALs in HDID-1 mice. (a) Experimental timeline of sirolimus treatment relative to DID. (b) Ethanol intake (g/kg) for Day 1 and across each 2-hour time period of Day 2. (c) Ethanol intake (g/kg/4 hours); main effect of sex (F(1,48) = 4.17; P = .047), but no significant effect of dose or sex by dose interaction. Data shown has been collapsed across sex (one-way ANOVA; F(3,52) = 0.53; P = .67). (d) Blood alcohol levels (mg %); no significant effects were found (F’s(1-3,48) < 1.6; P’s > .2). Data shown has been collapsed across sex (one-way ANOVA; F(3,52) = 0.80; P = .50).