Figure 2.

CKM members maintain similar but not identical promoter occupancy patterns at target genes. ChIP analysis for the CKM components indicated are shown cyclin C–activated (A) and -repressed (B) loci before and following H₂O₂ treatment. Two genes whose mRNA expression is not altered by H₂O₂ (Col4a1 and Sall1) are shown. Arrows indicate genes displaying a disconnect between loss in cyclin C occupancy compared with the other CKM components. Data obtained from ChIP were compared with a nonspecific control antibody (GFP). For all results, statistical significance is indicated by the following: *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.